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Follow-up studies largely fail to reproduce the 1999 finding that strained caregivers die sooner
Naomi Eisenberger and colleagues report that a 1999 finding of 63 percent higher mortality in strained caregivers has mostly failed to replicate. The correction matters to some 63 million US adults who give care, a role popular wisdom says can shave years off a life.
The Scientist · Science desk

What happened
- Writing in Biopsychosocial Science and Medicine in September, the team says considerable research instead links caregiving with living longer.
- Schulz and Beach followed more than 800 people for four years; about half had disabled spouses, and the half with healthy spouses served as the control group.
- Original participants who did not care for their disabled spouses died at the same rate as the strained caregivers, Eisenberger's team notes.
- The 1999 JAMA paper has been cited almost 5,300 times, including almost 300 times in the past two years.
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Why it matters
- constraint Because the control group had healthy spouses, the headline mortality figure cannot be read as the toll of caregiving alone; it folds in whatever risk comes with living beside a sick partner.
- decision Authors still citing the paper about 150 times a year now have to decide whether they are citing a result about caregiving or one about spousal illness.
- contradiction Correcting the record puts the researchers at odds with advocates like Utz, who worry that talk of benefits could erode the little help caregivers now get, while Eisenberger's team says an all-negative picture hides how care might protect health.
Over the four years of the original study, 103 participants died [6]. Schulz and Beach focused on one subgroup, spousal caregivers who reported considerable strain. Of those, 17 percent died, against 9 percent of the control group [7]. The raw gap is 8 percentage points [20]. Strain was measured by the caregivers' own self-reports [5].
The weak point is the control. The comparison that isolates caregiving sits inside the disabled-spouse half of the sample, between spouses who gave care and spouses who did not [4]. The headline comparison instead set strained caregivers against people whose spouses were healthy. Eisenberger says people with sick spouses and people with healthy ones occupy different realities, so comparisons between those groups are largely invalid [9]. On her team's reading, the 1999 data point to having a sick or disabled spouse as the thing that raised the chance of dying, whatever a person's caregiving status [9].
Schulz himself is among the researchers who have since disputed the idea. He coauthored a 2009 paper that did so, according to Science News [10].
In my view, the 1999 paper is a sound citation for the finding that people married to a disabled spouse died at higher rates as a group. It is a weak citation for the claim that looking after that spouse is what shortens a life.
The longevity finding deserves the same scrutiny. The Science News account does not say how many studies the review weighed or how they were selected, and an association with living longer does not show that caregiving causes it. The authors offer a hypothesis: they suspect a hardwired human propensity to help others in need softens caregiving stress [21]. Eisenberger also points to a 2003 study in The Gerontologist. In it, adult children who did not care for a severely disabled parent had more depression than those who did, though those researchers could not show causation [11].
Inflammation is the sharper biological lead. Most stressors, work burnout among them, are linked with chronic inflammation, and caregiving is less likely to show that link, the team says [22]. Eisenberger says understanding that difference could reveal how the body withstands stress [23].
The job is still hard by caregivers' own accounts. In a 2025 survey by AARP and the National Alliance for Caregiving, almost 65 percent of caregivers reported moderate or high emotional stress, and almost half reported financial difficulties [13]. Financial and emotional support for caregivers remains limited, the report notes [13]. "I don't like to take our foot off the pedal and say that caregiving is so positive because it's hard, and people need support," said Rebecca Utz, a sociologist and gerontologist at the University of Utah [15].
Eisenberger cared for her father through dementia until his death in January [18]. She describes her aim in modest terms. "I'm not suggesting everyone go out and engage in informal caregiving," she said. What she is trying to do, she said, is make informal caregiving seem less frightening [16].
What to watch
- The review's full study list and inclusion criteria, which would show whether the longevity association was adjusted for caregivers' health before they took on care.
- Studies that directly compare inflammation markers in caregivers with those in people under other chronic stressors such as work burnout.
- Whether caregiver-support groups, including AARP and the National Alliance for Caregiving, change how they describe caregivers' health risks.