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King's College London researchers linked more daily steps in 5,515 US adolescents to fewer anxiety and depression symptoms a year later. The study is observational, so step counts become a cheap marker to track, though it cannot yet show that adding steps lowers symptoms.
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York University researchers found macaque neurons shift their code for a still target's position after motion adaptation, as human perception does. The AI vision networks they tested showed no such shift, so the team proposes the illusion as a NeuroAI benchmark.
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Mount Sinai reports in Nature that blocking an amygdala-to-hypothalamus pathway in mice kept prior stress from amplifying later threat responses. Trauma-sensitization research now has one circuit to test. So far, every causal test of it has been in mice.
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Lund University scans of more than 1,000 people show Alzheimer's reorganizes brain connectivity along a path distinct from normal aging. If the result replicates, brain-wide connectivity could join amyloid and tau as a way trials judge whether a drug helps.
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Anglia Ruskin researchers linked six weekly music-making sessions to lower cravings and weaker frontal beta EEG in a 16-adult London addiction pilot. The beta signal hints at an objective gauge of craving relief for clinics, though only at pilot scale.
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University of Missouri researchers found four weeks of daily low-dose rapamycin raised brain blood flow only in healthy APOE4 carriers aged 45 to 65. That makes perfusion a measurable target for prevention trials, though a month of scans cannot show that fewer people go on to develop dementia.
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SUNY Upstate researchers report in PLOS Biology that oligodendrocytes use the Piezo1 channel to sense axon width and set how long each myelin segment grows. The work covers early myelination, so using the sensor to lengthen the short sheaths in chronic multiple sclerosis lesions is still only a proposal.
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Weill Cornell-led researchers found 18% of under-65 patients had cognitive impairment within two years of neck lymph node removal, versus 4-6% expected. Because the comparison is with population rates, the finding makes a firmer case for cognitive follow-up than for cutting less.
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Northwestern researchers found 35 young adults reacted 41 milliseconds faster to a visual cue while exhaling than while inhaling. That makes breath phase a source of variation in a standard clinical attention test, through a link the team cannot yet explain.
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European Academy of Neurology researchers link chronic insomnia to a 26% higher stroke risk across studies of more than 1.3 million people. The evidence is observational: strong enough to flag insomnia for closer checks, but it cannot show that treating insomnia prevents strokes.
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Mississippi State's kinetic model of copper and zinc speeding amyloid-beta clumping matches atomic force microscopy data, the university says. Its two simulated anti-plaque strategies could guide lab work if the fit holds on data the equations were not tuned to.
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UCSF researchers tied 16 blood proteins that shift with menopausal hormones to a 15% higher Alzheimer's risk in nearly 12,000 older women. Those women were in their 60s and 70s, so a menopause screening test would need a study that follows the same women from midlife.
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Kyoto, Harvard and UCLA researchers find shared noise in up to 21,000 mouse visual cortex neurons slows sensory information growth without capping it. The finding challenges a 30-year-old coding assumption, but beyond the recorded cells it rests on extrapolated power laws.
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Anna Braniecka's Clinical Psychology Review paper finds humor-based therapy fails in acute depression and helps most in remission or mild illness. Clinicians get a timing rule, and relatives get a warning about forcing cheer on someone mid-episode.
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Weill Cornell biophysicists used cryo-EM to map the pocket where trace amounts of the lipid PIP2 dock onto rod-cell CNG channels and hold them shut. The site is a candidate drug target for inherited retinal degeneration, so far studied only in synthetic membranes.
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Magnetoencephalography in 263 patients and 75 controls yielded five connectivity groups, one with widespread reductions in coupling and one with the strongest coupling in the study, each tracking a different symptom mix.
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Mehdi Borjkhani's group at ICTER built a three-variable rate model of the primary visual cortex in which two feedback loops already known in cortex pulled variability from 0.325 to 0.024 while orientation tuning stayed in the macaque range.
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A Tulane team tracked 277,489 middle-aged adults and found that exercise, diet, sleep and not smoking blunted the physical cost of objective isolation while leaving the psychiatric cost of feeling lonely largely in place.
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An Aarhus-led team injected 300-nanometre semiconductor particles into mice with advanced retinitis pigmentosa and recorded light-driven activity in the visual cortex, a route to restoring light sensitivity that does not depend on the patient's mutation.
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A Hebrew University team traced cocaine's compulsive licking in mice to the orofacial action-selection circuit of the ventrolateral striatum, then turned the behavior off and on by moving the region's two competing pathways.
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