Topic
Imaging techniques that resolve structures finer than the conventional optical diffraction limit, widely used to visualize nanoscale biological structures.
Researchers led by the University of Göttingen report in Nano Letters that self-blinking dyes let nanobody labels work in single-molecule microscopy. The team says the pairing keeps the probes' labelling accuracy while making super-resolution imaging simpler and more reproducible.
Reality
Illinois researchers paired super-resolution imaging with machine learning to track grass diversity and C3-C4 balance at one site over 25,000 years. That makes a plentiful fossil countable by type, though the evidence so far rests on one sediment record.
Reality
Ronald Micura's group in Innsbruck and Aiming Ren's in Zhejiang solved the RNA imaging tag with and without dye bound, and the residue that moves, G38, is what lets the dye leave again fast enough to blink.
Reality
Chromatin looseness has been a research-microscope quantity, measured on cells prepared specially to be looked at. A dye that blinks on its own reaches it inside the archived wax block, which is where the patients are.
Reality
A framework called REID images living cells with light made inside them, hitting 100 nm detail in 20 ms exposures and 41 hours of continuous mitochondrial footage.
Reality