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Peer-reviewed scientific journal published by Nature Portfolio covering new experimental and computational methods in biology and life sciences research.
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Sebastian Böcker's Jena group reports in Nature Methods a tool that predicts chromatography retention times on new lab systems without retraining. Whether that makes retention time a dependable filter for identifying unknown molecules depends on how large its prediction errors are.
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A Nature Methods team reads millions of individual tau molecules with a repeating antibody panel and finds a non-random pattern of phosphorylation, though the single-timepoint census leaves the order in which those marks arrived unresolved.
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The authors accept that de novo protein sequencing is worth chasing, and argue the field has crowded into it while size-tunable solid-state pores sit underused for measuring the assemblies that biology actually builds.
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A paper published by Nature treats stray RNA molecules as a characterizable artifact and corrects them statistically after cells have been drawn. The abstract reports better cell-state separation.
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MemBrain v2, published in Nature Methods by groups in Munich and Basel, reports a 91% F1 score locating membrane protein complexes on new membranes after a single one was labelled by hand. Its authors put the time saving at weeks down to a few hours.
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Johns Hopkins researchers ran a miniature brain microscope autonomously through a full day of mouse behavior, recording neuronal activity, blood flow and oxygenation, and catching spontaneous seizures hours after a drug dose.
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Spatial-ATAC-Hi-C pulls contact maps and accessibility signal from one barcoded spot of mouse and human brain tissue, which is how its authors come to report copy number and structural variants region by region across glioblastoma and astrocytoma.
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The Nature Methods platform pairs stimulated Raman imaging with CODEX typing, so metabolism stops being predicted from transcripts. Its redox proxy still cannot name the cause.
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The startup opened what it calls the world's largest human data center last week. Its diagnosis of the field is testable; most of the evidence for its own machines is self-reported.
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