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Peer-reviewed scientific journal published by the American Chemical Society covering nanoscience and nanotechnology research.
Georgia Tech and Emory researchers found the gut site where a lipid-nanoparticle mRNA dose lands, cheek to rectum, changes which organs it reaches in mice. That turns the delivery site into a tool for aiming oral vaccines at lymph nodes or GLP-1 therapy at the pancreas.
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Northwestern chemists built zirconium-loaded melanin nanoparticles that cut a toxic organophosphorus byproduct by 50% within 10 minutes. The team pitches them for protective clothing, and so far that use rests on the reaction chemistry and the group's earlier work dyeing synthetic fabrics.
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IIT researchers built 500-nanometer polydopamine nanotubes that heat under infrared light and generate current and release dopamine under ultrasound. The group, writing in ACS Nano, calls the trio a first for one organic structure, though ultrasound drives two of its effects together.
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MIT chemical engineers built an automated process that lets developers set a lipid nanoparticle's size and shape before testing which one performs best. It replaces bench trial-and-error, though the study does not show a chosen size reaches a chosen organ.
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UT Austin, Eli Lilly and Boston University found a Tris buffer keeps mRNA nanoparticles potent through freezing, where citrate cannot. Only 5% to 10% of an mRNA dose reaches its target, so the storage solution shapes how much material a patient needs.
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Fluorescence lifetime gives a second axis for separating labels. A Göttingen-led team used it to read eight proteins from a single stained cell on an ordinary confocal with lifetime detection.
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In two companion papers from the University of Eastern Finland, modes sharing a topological class locked together into ultrafast pulse modulation, while modes of differing topology and polarization lased side by side with no mutual coherence.
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MoOCl2 is metallic along one crystal axis and dielectric along the perpendicular one, and an Okayama-led team used that split to measure a dielectric quality factor of 45.3 in nanodisks on gold, about 5.7 times the plasmonic mode's.
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An Amsterdam group reports it can put a tungsten disulphide monolayer exactly where it wants it, with near-unity yield. The limits worth watching are the 140 C melt step and the millimetre of usable area.
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University of Sydney researchers want to spare cleft-palate children the decade-long wait for a graft cut from their own body. So far the case rests on one eight-week endpoint in a preclinical model the announcement does not name.
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An ACS Nano study varied only the lipid tail on peptide amphiphiles and found the most cohesive nanostructures got stuck inside brain endothelial cells while looser ones crossed in vitro.
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In mice, a peptide-PEG agent given before dosing cut liver expression several dozenfold and raised spleen expression severalfold, according to work in ACS Nano.
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