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Peer-reviewed journal published by the American Association for the Advancement of Science, covering original research across all scientific fields.
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University of Copenhagen researchers report in Science that cold raised the mitochondrial carrier SLC25A34 90-fold in mouse brown fat after 24 hours. Because the body clock and dietary fat also control it, the lead author sees a possible new obesity-drug lever in work done so far in mice.
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Mathew Domeier's University of Oslo team finds four fast bursts of true polar wander recorded in ancient sea levels over the past 190 million years. During those bursts, he says, the poles moved faster than most tectonic plates do, fast enough to possibly affect climate.
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Northwestern scientists grew supramolecular threads about 100 times more massive than any known protein, with lengths and charge segments set by design. Cultured neurons exposed to the threads grew and formed more synapses, an effect the team credits to that precision.
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Science's women's health issue traces sex differences in disease across all ages, including functional pain women experience at about twice men's rate. Its editors say political attacks and research funding cuts make the work urgent.
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Stephen Harrison's Harvard lab imaged a rotavirus breaking into a cell and found that VP7, not the protein he expected, forms the pore that releases its genome. The team reported the mechanism Sept. 10 in Science, and Harrison sees it as a lead on delivering large gene therapies into cells.
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Gallup found the tie between heavy AI use and job-loss fear ran 6.8 to 11.1 points weaker where workers felt respected or cared for at work. That makes part of any AI rollout a management job.
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Harvard's lung-on-a-chip has nearly 5,400 citations since 2010, but most non-animal test methods have yet to be rigorously tested, IEEE Spectrum reports. Validation means head-to-head runs against animal experiments, so animal data remains the yardstick for now.
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SWANS, described in Science, sent faint pulses about 40 centimeters through a rat's tissue to switch on a nerve-stimulating implant in its hind leg. Dropping the radio shrinks the devices to syringe size, though that range was measured only in rats.
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Bei Wang's team searched backwards from each magnitude 3 quake and nearly always found a smaller precursor. That number measures how often a warning existed after the fact. A shutdown rule needs a different number: how often such a warning would have meant anything in advance.
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The protection ran through the same serotonin receptor that carries the hallucinations, though a non-hallucinogenic compound worked too, and a randomised trial in about 80 patients is due to start in November.
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Nebraska physicists report in Science that hafnium oxide is intrinsically antiferroelectric, holding that order in films 0.6 nanometers thick. The lead-free compound, common in electronics, gains a firmer claim on capacitor, memory and cooling uses, so far on evidence from single-crystal films.
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Memorial Sloan Kettering researchers used nanoparticles to kill a scar-driving macrophage subset, restoring immunotherapy in mice with liver and lung cancer. The Science paper points to the tumor's fibrotic barrier as a route past immunotherapy resistance.
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Cornell scientists report in Science that BC200, an RNA gene abundant in human neurons, jumped twice into a poxvirus about 100,000 years ago. The team says it is the first human gene seen both moving and in cellular use, though what it does in neurons is still poorly understood.
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Quantum jumps were caught in trapped ions in 1986 and in photons in 2007. A resonator that rings for two milliseconds, read out by a superconducting qubit, now shows a single phonon going to zero as it happens.
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Crick researchers report that two four-subunit RAD51 paralog complexes assemble and cap DNA repair filaments, after about 20 years of stalled study. The genes sit in the BRCA pathway and the structures may help explain disease mutations, but the work includes no drug or patient data.
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ELTE researchers found dog brains tracked consonant-built nonsense words 42% more strongly than vowel-built ones, a bias previously seen only in humans. Every dog lived with Hungarian speakers, so the study cannot yet say whether hearing speech is what put the bias there.
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Max Planck researchers followed 21 wild orangutans to independence and found that each infant's mix of watching and exploring tracked its eventual diet. Strong watchers who rarely explored still ate widely, though the diet data cover 13 animals and end at independence.
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More than 120 scientists, mostly ERC grantees, argue in Science that fragmented funding keeps Europe's strong research from reaching the market. Their main fix is to hand ERC Proof of Concept grants to the European Innovation Council, a proposal that rests on the members' own experience and has not been tested against outcomes.
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Physicists mapped the electronic topology of 8,872 atomically thin materials and named over 1,600 twisting candidates in two Science papers. The lists are calculations that tell labs where to look, and testing them in twisted devices comes next.
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Daniel Kattnig modelled a semicircular canal under the conditions most favourable to electromagnetic induction and found the bird's own thermal fluctuations leave a directional signal far too slow to steer by.
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