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Peer-reviewed scientific journal published by Cell Press covering original research across molecular, cellular, and systems biology.
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Broad and MIT researchers watched single receptors on live cells for over 16 minutes and found that normal HER3 forms stable pairs. Cancer-linked HER3 mutations loosened those pairs, and the idea that this frees HER3 to drive signaling is still the team's working model.
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Mayo Clinic researchers tie colorectal and breast cancers diagnosed at 50 or younger to distinct gut microbes, using stool from 1,364 patients. The signals give researchers named bacteria to test next, though the data cannot yet say whether those microbes drive early disease or follow from it.
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Helmholtz Centre for Infection Research scientists built Metax, a profiler that judges a microbial DNA match by how widely its reads spread across the genome. It targets the false positives current profilers can report, a problem sharpest in low-biomass samples, where host and contaminant DNA swamp the microbial signal.
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The wiring of a male fruit fly's brain and nerve cord is now public, and the payload for anyone planning a bigger map is a claimed thousandfold gain in connectome efficiency whose denominator nobody has stated.
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EMBL researchers report in two Cell papers that 3D imaging of frozen bacteria catches protein production coupled to transcription and membrane transport. Lead author Joe Dobbs calls both proofs of concept built on still images of flash-frozen cells.
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Mount Sinai researchers report that APOE4 turns vessel-support cells into scar-forming ones, and that blocking TGF-beta reversed it in aged mice. Both reversals so far are in aged mice and in stem-cell-derived human tissue.
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Guidance published by GEN draws the line between presentation and manipulation at consistency and disclosure. The case for archiving unprocessed files is prudential, since the article reports no rate of irregularities.
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Incendiamoeba cascadensis, from Lassen Volcanic National Park, divides at 63 degrees Celsius and still hunts for food at 64, one degree past a membrane-stability limit its lead author says may have narrowed the search.
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UC San Diego researchers treated cancer cells with 25 mitochondria-perturbing compounds, collected 40,000 single-cell 4D movies, and trained a model that sorted the drugs by mechanism with the labels withheld.
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Bigelow Laboratory's GORG-Dark holds more than 9,600 genomes, each from a single sorted cell, including samples from the Mariana Trench and the Antarctic, and the Cell paper reports widespread genetic potential for chemoautotrophy.
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A repurposed retroviral shell protein lets a culture report its own gene activity again and again instead of once, so a single well becomes its own before-and-after control, at population-average resolution.
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Fu Qiaomei's team sampled 11 sites in northwestern China spanning some 1,700 years. Nine yielded western-derived crops or livestock, and none of the 149 individuals carried detectable western Eurasian or Central Asian ancestry.
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Steven Banik's group treats sub-threshold protein changes as a detection problem rather than a biological one. Their engineered readout is meant to hold its signal in small numbers of cells, which is what a screen actually needs.
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A Cell paper reconstructs organ formation by ordering hundreds of static mouse follicles by molecular age. The animation is an inference, and the Foxn1 delay finding rests on it.
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DANDELION ranks genes by position in trans-regulatory networks rather than distance from a variant. Its asthma shortlist survived CRISPR screens and mouse models. The denominator is missing.
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A UK molecular biologist says dozens of cell-ageing studies used an antibody against a bacterial protein to detect a mammalian one. It is his third reagent flag in about three months.
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A Dongguk University team reports in Cell that a promoter borrowed from the Lgr4 gene drives expression in mice under a 2.0 millitesla, 60 hertz field, and returns to baseline in 24 hours.
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A genome-wide CRISPR screen tied polyamine depletion to GPX4 dependence. A new genetically encoded reporter now puts numbers on redox-active iron inside living cells.
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A screen of 337 virus genomes found stabilizing elements; one, Pt1, pushed linear mRNA half-life from 7.6 to 23.1 hours by recruiting nuclear poly(A) polymerases in the cytoplasm.
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