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Invest3 publishers3 min readPublished Updated

Basecamp Research raises more in one round than in its first seven years combined

S32 led a $140M round that takes Basecamp Research's total funding to $225M since 2019. Two of the sixteen named backers, NVIDIA and Anthropic's Anthology Fund, are also partners on the dataset its models train on.

The Investor · Invest desk

Photograph accompanying Basecamp Research raises more in one round than in its first seven years combined
Photo: yahoo.com

What happened

  • Basecamp Research said on September 23 it had closed an oversubscribed $140M Series C led by S32, to train a new generation of its EDEN models and push AI-designed therapeutics towards clinical development.
  • NVIDIA's venture arm NVentures returned as an investor and Anthropic's Anthology Fund came in new, alongside state-backed and philanthropic money in the same round.
  • Andy Conrad, a general partner at S32 and former chief executive of Google's Verily, joins the board of directors.

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Why it matters

  • decision Recruiting Richard Pearce from Biogen as chief business officer puts pharmaceutical partnership revenue ahead of a solo drug programme, so the people Basecamp has to convince next sit in business development.
  • exposure The NATO Innovation Fund and the UK government's Sovereign AI Fund now hold equity in a pipeline that has not been dosed in a human. That puts public money on preclinical risk.
  • contradiction PR Newswire lists Anthropic's Anthology Fund among the backers while tech.eu headlines Anthropic itself, and the fund is a partnership with Menlo Ventures, leaving Anthropic's own exposure unquantified.
  • capability Cash of this size lets Basecamp train the next EDEN generation before any partner pays for access, and the Trillion Gene Atlas stays proprietary while deals are negotiated.

Basecamp has raised $225M since it was founded in London in 2019, and $140M of that came in this round, so about $85M covered the first seven years. The new money is roughly 1.6 times everything raised before it, and 62 percent of the company's lifetime capital.

What it buys, on the company's own account, is a new generation of EDEN models and a pipeline moving towards clinical development, beginning with in vivo cell therapy. That means reprogramming a patient's cells inside the body by pairing long designed DNA sequences with large serine recombinases that integrate them into the genome. The cost problem Basecamp names is manufacturing, which for today's cell therapies runs into hundreds of thousands of dollars per patient. Read that phrase as $200,000 to $500,000 and the whole round equals between 280 and 700 patients of current-generation production. The platform case is that treating inside the body removes the per-patient factory step.

Sixteen investors are named. Split evenly that is under $9M each, and the lead will have taken more than a sixteenth. Six of the sixteen are not conventional venture funds: the NATO Innovation Fund, the UK government's Sovereign AI Fund, the Rockefeller Foundation, King Philanthropies, NVIDIA and Anthropic's Anthology Fund.

The last two were involved before the round. Both are named as partners in building the Trillion Gene Atlas, alongside PacBio and Ultima Genomics. Neither release says whether cash moves between them for compute or model work. S32, which led, was founded by Bill Maris.

"We believe the future of medicine lies in reprogramming the body to repair itself. We design the models and the medicines to teach it how," said Glen Gowers, co-founder and chief executive. Andre Hoffmann, vice-chairman of Roche, invested personally and said that "Personalised, AI-designed therapeutics represent the next transformation of that journey."

The releases name a modality. They do not name a molecule, and they give no valuation, no lead candidate and no filing date. In my view the $140M is a bet on the dataset first and a drug second, because the Atlas was assembled through access and benefit-sharing partnerships in more than 30 countries across all seven continents. A rival cannot replicate those partnerships. The case against: "strong preclinical results across multiple modalities and disease areas" is Basecamp's own characterisation. Preclinical breadth in a press release has a poor record of surviving a first patient. I would drop the dataset view if the first disclosed pharma deal pays chiefly for model access at a modest upfront, since that would say buyers are pricing the software. Until some partner pays a disclosed sum, this round is the only external price on EDEN.

What to watch

  • A pharmaceutical partnership with disclosed upfront and milestone payments, which would price EDEN outside an equity round.
  • A first-in-human or IND filing naming a lead in vivo cell therapy candidate and its indication.
  • Any later disclosure of whether cash moves between Basecamp and NVIDIA or Anthropic for compute and model work.
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