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Peer-reviewed scientific journal publishing research on metabolism, covering metabolic diseases, cellular metabolism, and related physiology studies.
Cedars-Sinai-led researchers found that restoring the enzyme UBE2N reduced fat buildup, inflammation and scarring in mouse livers. The Nature Metabolism study offers a drug target for slowing fatty liver disease, backed so far only by mouse data.
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University of Florida researchers linked glucosamine use to a 25% higher chance of mild cognitive impairment becoming dementia in patient records. The team calls it an association that a clinical trial must test.
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Twenty people with early-stage Huntington's disease ate inside a six-to-eight-hour daily window for 12 weeks. They kept their weight and lean mass, and gained half a point on a severity scale that normally falls. The pilot had no control arm.
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A Rockefeller group reports in Nature Metabolism that free cysteine pulls iron out of ferritin and into mitochondria, while glutathione, built on the same reactive sulfur group, leaves the stored iron alone.
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A Northwestern-led team in Nature Metabolism places metformin's main action on mitochondrial complex I in intestinal cells, using mice given a substitute enzyme that does the same job but ignores the drug.
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A Cambridge mouse study locates the GIP paradox in anatomy: agonists act through the brainstem, antagonists release a hypothalamic brake. Combination design becomes a targeting question.
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