Nature Aging is a peer-reviewed scientific journal, part of the Nature Portfolio, publishing research on the biology and mechanisms of aging.
Standard gene models leave out short open reading frames, so a Salk team built a search database that includes them and pointed it at existing proteomics data from postmortem frontal cortex samples.
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The MIT group measured skin and lung cells from 2-month-old and 26-month-old mice both ways at once, using the destructive sequencing read to label the optical one. Human tissue, the authors say, is next.
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Across a full mouse reproductive lifespan, the share of eggs that had begun growing stayed flat. The Barcelona group takes that as a sign the ovary tracks its own supply, and says it does not yet know the signal.
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A 42-person plasma screen found C3 falling on an 11 to 14 percent calorie cut, and mice supply the causal half. The harms that justify drugging it came from a much deeper diet.
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A subcutaneous myocyte graft gave mice muscle, bone and immune gains. The mice were also free to roam their cages, which is the one condition the intended patients do not share.
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A UK molecular biologist says dozens of cell-ageing studies used an antibody against a bacterial protein to detect a mammalian one. It is his third reagent flag in about three months.
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