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Vijay Sankaran's team pooled genetic data from more than 28,000 people and found a BACH2-NRF2 axis that switches on fetal hemoglobin without going through BCL11A. Blocking it in cells raised fetal hemoglobin, pointing drug programs at a target beyond Casgevy's gene edit.
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Formulators expected fluid lipid membranes to leak fastest. With the water-soluble neurotoxin tetrodotoxin inside, the most unsaturated liposomes released it slowest and numbed a rat's leg for weeks.
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A survey of more than 300 executives has a majority planning to lean harder on contract manufacturers even as batch prices climb. McKinsey reports rising cost sensitivity and thin supplier loyalty among the same buyers.
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In a GEN discussion, Pfizer's Bhanu Chandra Mulukutla and Wenge Wang describe media optimization as a chemistry and plant-operations problem, and the account is practitioners' reasoning.
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A Morgridge Institute team read metabolism in unlabeled immune cells and left the sample usable afterwards, which makes cell-therapy manufacturing the likelier first customer, though nobody has yet tied the signal to a product outcome.
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The Hollings group puts lysyl oxidase inside the cancer cell, running its mitochondria, and reports that shutting it down leaves a backup survival pathway a second drug can close. The work is preclinical, and thinly quantified.
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A modulator credited with both raising and lowering aggression in flies can now be probed one cell type at a time, some types as small as a pair of neurons, moving the story from chemical to cellular resolution.
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A University of Toronto group packed engineered tRNAs into inhalable lipid nanoparticles and recovered full-length CFTR in three model systems, which turns a mutation class gene editing struggles with into a question about delivery and dosing.
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Northwestern and Salk researchers report a BLA to mPFC projection that grows more excitable in isolated male mice and less excitable in females, with drinking following each direction.
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MassBio's annual snapshot pairs a recovering VC, IPO and M&A market with a 39% fall in seed capital, a 6% drop in NIH awards and 3,605 lost jobs.
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DANDELION ranks genes by position in trans-regulatory networks rather than distance from a variant. Its asthma shortlist survived CRISPR screens and mouse models. The denominator is missing.
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A Warsaw group has indexed the substrate receptors of cullin-RING ligases and mapped their disease links, giving rare-disease geneticists a specific failure to test rather than a gene name.
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Marama Labs says an integrating sphere strips scatter so LNP payload reads in 15 seconds without lysis or dyes. The precision figures come from the CEO and a study the company co-authored.
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A genome-wide CRISPR screen tied polyamine depletion to GPX4 dependence. A new genetically encoded reporter now puts numbers on redox-active iron inside living cells.
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