Two decades after Janelia proposed the project, the adult fly connectome is finished. The 1,000-fold efficiency gain credited with making it possible is measured against the institute's own 2008 forecast.
Reality
- Evidence60
- Adoption40
- Hype gap+25
- Incentives55
- Confidence62
University of Geneva researchers find fruit-fly clock neurons inhibit dopamine relay cells on a 24-hour rhythm to gate daytime wakefulness. That puts the step where time of day becomes alertness in a middle layer of cells, so far shown only in flies.
Reality
- Evidence55
- Adoption
- Insufficient
- Hype gap+25
- Incentives30
- Confidence60
Baylor researchers tied reduced BRSK1 function to a neurodevelopmental disorder in 10 people from seven families after an AI tool flagged the gene. The variant was already in sequencing data that standard analysis had left unsolved, so the gain came from reading that data again, and fruit-fly experiments supplied the functional evidence.
Reality
- Evidence62
- Adoption
- Insufficient
- Hype gap+30
- Incentives40
- Confidence60
A modulator credited with both raising and lowering aggression in flies can now be probed one cell type at a time, some types as small as a pair of neurons, moving the story from chemical to cellular resolution.
Reality
- Evidence62
- Adoption15
- Hype gap+8
- Incentives55
- Confidence52
A Penn State team pulled native RNA polymerase II complexes out of fruit fly embryos and found some missing two of the canonical 12 subunits. The purified picture was tidier than the cell.
Reality
- Evidence45
- Adoption15
- Hype gap+35
- Incentives65
- Confidence42