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Science1 publisher2 min readPublished

Three independently built diamond sensors recorded the heart's magnetic field at room temperature

A German project measured cardiac magnetism using nitrogen-vacancy centers in a diamond of less than half a cubic millimetre, working at room temperature and off the skin.

The Scientist · Science desk

Illustration accompanying Three independently built diamond sensors recorded the heart's magnetic field at room temperature

What happened

  • Physicists at Johannes Gutenberg University Mainz report in Science Advances that nitrogen-vacancy centers in diamond can pick up the heart's magnetic field, using a sensor built by doctoral student Muhib Omar.
  • The DIAQNOS project used three magnetometers developed independently by the Mainz group, the Universities of Stuttgart and Freiburg, and the startup Q.ANT GmbH, each measuring the magnetic field of the heart.
  • The Mainz sensing element is a truncated diamond pyramid of less than 0.5 cubic millimeters, small enough to carry, and it works at room temperature on the skin.
  • The team's stated conclusion is that German quantum technology is ready to move toward medical applications, and the same work identified the improvements still needed to get there.

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Why it matters

  • capability A probe that can be placed at any point on the body puts two measurements within reach that the Mainz group names: 3D reconstruction of the heart's electrical conduction system, and fetal cardiac activity.
  • cost The expense in magnetocardiography has sat in the magnetometer, so a room-temperature sensor is where a cheaper cardiac magnetic exam would have to begin.
  • constraint Without published sensitivity figures, a clinical buyer cannot tell whether the diamond systems reach the signals existing installations already resolve. It stays a research result until those numbers appear.

An NV center is a gap in the diamond lattice sitting directly next to a nitrogen atom that has taken a carbon's place [5]. Its energy levels respond to what surrounds it, and reading them gives magnetic and electric fields, temperature and mechanical stress with high precision [6]. That is why the hardware can be small: the sensitive part is the crystal. Take the cube root of half a cubic millimetre and you get 0.79, so an equivalent cube would sit under 0.8 mm on a side [21].

Two of the three instruments applied a magnetic bias field to filter out interference from their surroundings, and one did not [22]. The one that did not is the Mainz fiber-based magnetometer, built as a portable endoscope [8].

Magnetocardiography demands very sensitive magnetometers, and that requirement is what has tied it to costly, complex instruments such as SQUIDs and optically pumped magnetometers [12]. The phys.org account of the study does not state the sensitivity the three diamond systems achieved [20]. Room-temperature operation is demonstrated [10]. Whether a diamond probe resolves a cardiac trace as well as a SQUID, which does not run at room temperature [10], decides whether one can stand in for the other.

Arne Wickenbrock, who coordinates the DIAQNOS project from Mainz [2], dated the effort. "These results are the product of over 10 years of development work," he said [16]. He described the group's approach as working "closely with neurosurgeons to ensure that our technologies do not remain confined to the laboratory but find clear practical applications" [17]. Of the sensors themselves, he said they are "characterized by fast initialization, excellent biocompatibility and stable operation over a wide temperature range" [18].

The comparison the group draws is with electrodes. ECG is the widely used method and it is susceptible to the differing conductivity of body tissues; on burn wounds, electrodes cannot be placed on the skin at all [13]. A magnetic measurement needs no contact and is only minimally affected by conductivity [11]. The researchers also name myocarditis and epilepsy as conditions a sensitive enough sensor could catch early, and they frame those as possible future uses [15].

What to watch

  • Noise-floor figures in the Science Advances paper, and whether the systems needed a shielded room, would decide whether NV sensors can stand in for SQUIDs.
  • Whether the fiber endoscope gets tested during surgery with the neurosurgeons Wickenbrock says the group works with.
  • A first attempt at fetal magnetocardiography or 3D conduction-system mapping using the diamond sensor.
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