lab
Medical school and research arm of Mount Sinai Health System in New York City, spanning neuroscience, genetics, and clinical research.
No evidence-backed relationships are recorded.
Nirao Shah's Stanford team found that female mice need a neuron type making up under 0.001 per cent of brain cells to sustain a pregnancy. Any role in unexplained miscarriage or failed IVF in women is still a hypothesis, because the deletion experiment can only be done in animals.
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Mount Sinai reports in Nature that blocking an amygdala-to-hypothalamus pathway in mice kept prior stress from amplifying later threat responses. Trauma-sensitization research now has one circuit to test. So far, every causal test of it has been in mice.
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Mount Sinai researchers report APOE4 turns brain pericytes into scar-making cells, and blocking TGF-beta reversed the change in aged mice. That gives drug developers a vascular target in carriers of the strongest known genetic risk factor for Alzheimer's.
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Mount Sinai's 30-person pilot found an at-home magnetic headset beat a sham on long COVID cognition, with gains holding a month after treatment ended. Only 10 people were in the sham arm, so the result argues for a larger trial before anyone calls the headset a treatment.
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Mount Sinai researchers estimate that Phelan-McDermid syndrome affects about 1 in 7,300 people, more than 45,000 of them in the US. The figure is modelled from 180,000 tested autistic people, and the authors say the missing diagnoses matter as targeted trials begin.
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Mount Sinai researchers report that APOE4 turns vessel-support cells into scar-forming ones, and that blocking TGF-beta reversed it in aged mice. Both reversals so far are in aged mice and in stem-cell-derived human tissue.
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Mount Sinai and CPTAC collaborators measured DNA, RNA, proteins and protein modifications in tumors from patients aged 83 days to 40 years. Molecular profiles and survival split adolescents and young adults into two groups.
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Researchers at Mount Sinai counted drug trials collecting wearable data on ClinicalTrials.gov, and ten years of growth turned out to be gradual, with the researchers quoted by Nature split on whether sensor capability or validation work is the holdup.
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Mount Sinai's Nature paper argues that neurons trade repair for stress management after injury. Deleting or drugging the aryl hydrocarbon receptor tipped that balance back toward rebuilding, in mice.
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A matched comparison of 471 burn patients found shorter stays and half the complication rate with intact cod skin. The trial now running does not test that comparison.
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Systemic TIMP2 injections moved aged mouse microglia out of pro-inflammatory states and restored debris clearance. The press material omits dose, journal, and any cognitive readout.
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