A Baylor College of Medicine team used a structure-prediction workflow called GluePlex to find where a molecular glue grips the protein VAV1 before any experiment showed it. A separate group later reached the same conclusion in the lab.
Reality
- Evidence72
- Adoption15
- Hype gap+8
- Incentives68
- Confidence62
Baylor researchers tied reduced BRSK1 function to a neurodevelopmental disorder in 10 people from seven families after an AI tool flagged the gene. The variant was already in sequencing data that standard analysis had left unsolved, so the gain came from reading that data again, and fruit-fly experiments supplied the functional evidence.
Reality
- Evidence62
- Adoption
- Insufficient
- Hype gap+30
- Incentives40
- Confidence60
Baylor researchers report in Nature Cancer that stroke speeds glioma growth in mouse and human models by remodeling two brain-cell populations. Reversing the change in those cells slowed the tumors and pointed to SLC4A4 and CCL2 as targets.
Reality
- Evidence55
- Adoption
- Insufficient
- Hype gap+10
- Incentives
- Insufficient
- Confidence50
In mice, pregnancy turns up an SK3 potassium channel that quiets dorsal raphe serotonin neurons and raises the pull of palatable food. The team tested the channel in both directions before tracing its path to the reward system.
Reality
- Evidence45
- Adoption10
- Hype gap+22
- Incentives65
- Confidence50
A 3-year-old whose liver cancer outlasted surgery and three lines of chemotherapy has been in complete remission for a year after CAR T cells given entirely in the outpatient setting, Baylor doctors report.
Reality
- Evidence62
- Adoption8
- Hype gap+30
- Incentives55
- Confidence48
Risk this large has been hard to measure because the variant is so rare, and the estimate exists because a consumer genetics cohort held 641 carriers when two major biobanks held 21. A CT screening trial is now running.
Reality
- Evidence70
- Adoption22
- Hype gap+8
- Incentives45
- Confidence66
The Aug. 10 order also cuts the routine childhood list from 18 vaccines to 11 on the argument that the United States is out of step with Europe, and the pediatricians who have read it say no new safety or efficacy data came with it.
Reality
- Evidence66
- Adoption25
- Hype gap+45
- Incentives55
- Confidence58
Low-intensity sound wave treatment for erectile dysfunction is sold session by session in cash-pay clinics. Cochrane reviewed 21 studies and found the results too variable to trust.
Reality
- Evidence34
- Adoption58
- Hype gap+52
- Incentives71
- Confidence44