Topic

Tuberculosis

Infectious disease caused by Mycobacterium tuberculosis, usually affecting the lungs and treated with multi-month combinations of antibiotics.

Current clusters

science1 publisher

An evolved enzyme makes only the TB-active form of an oxazolidinone building block

Frances Arnold's Caltech lab reports in Nature an enzyme, improved by directed evolution, that builds the (S) stereocenter directly, so a step that usually discards half its output no longer has to. It is still proof of concept.

Publishers:phys.org

Reality

Evidence62
Adoption: Insufficient
Hype gap+12
Incentives58
Confidence55

science1 publisher

Corramycin kills drug-resistant TB cultures by locking gyrase onto severed DNA

A team at HIPS, the Institut Pasteur and Universite Paris Cite reports that corramycin attacks the same enzyme as fluoroquinolones by a different route and stays active against isolates those drugs no longer touch. An earlier program dropped the compound over production cost.

Publishers:phys.org

Reality

Evidence58
Adoption: Insufficient
Hype gap+22
Incentives66
Confidence62