science2 publishers
SFPQ condensates keep neurons' two-megabase genes transcribing to the end
An Ehime University team reports that SFPQ binds newly made RNA and uses it to build nuclear compartments where elongation, splicing and chromatin remodeling proceed together. Its autism and ALS link rests on overlapping gene lists.
Reality
- Evidence62
- Adoption
- Insufficient
- Hype gap+30
- Incentives48
- Confidence58