Topic

Orexin signalling

A brain peptide system, described in 1999, in which two related peptides act on two G protein-coupled receptors in the hypothalamus to promote wakefulness. It is the target of insomnia antagonists and narcolepsy agonists.

Current clusters

science2 publishers

Orexin's discoverers win the Lasker basic-science award a month after the first agonist approval

Emmanuel Mignot and Masashi Yanagisawa reached the same wakefulness peptide from opposite directions. The drug class that followed now holds one narcolepsy approval and a much larger set of untested hopes.

Publishers:livescience.comstatnews.com

Reality

Evidence78
Adoption52
Hype gap+12
Incentives40
Confidence74