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Live Biotherapeutics — Clarity Today

Topic

Live Biotherapeutics

Engineered living microbes proposed as controlled delivery vehicles for therapeutic metabolites.

Current clusters

science2 distinct publishers

A genetic switch for gut Clostridia: TMA and DCA turned on and off inside live mice

A Nature paper reports promoter and CRISPR toolsets that transfer across distantly related gut Clostridia, then uses them to toggle two host-relevant metabolites in mice. The methods stay paywalled.

Publishers:nature.com · phys.org

Reality

Evidence60
Adoption15
Hype gap+18
Incentives58

Confidence62