Topic

Calorie restriction

Sustained reduction of energy intake without malnutrition, studied in animals and humans for its effects on lifespan, immune function and metabolic health.

Current clusters

science1 publisher

Semaglutide added nearly 100 days to the median lifespan of 20-month-old mice

An NIH-funded UC Berkeley team dosed old, healthy female mice, then fed a second group 24% fewer calories to match what the drug's appetite suppression achieved. The drug still did more on memory and blood sugar.

Publishers:sciencedaily.com

Reality

Evidence62
Adoption: Insufficient
Hype gap+22
Incentives58
Confidence55

science1 publisher

Yale pins part of calorie restriction's benefit on one protein, and it comes from fat, not liver

A 42-person plasma screen found C3 falling on an 11 to 14 percent calorie cut, and mice supply the causal half. The harms that justify drugging it came from a much deeper diet.

Publishers:sciencedaily.com

Reality

Evidence60
Adoption: Insufficient
Hype gap+32
Incentives70
Confidence55