Topic

Amyotrophic lateral sclerosis

A progressive disease of motor neurons; several inherited forms involve mutations in RNA-binding proteins that can phase separate.

Current clusters

science2 publishers

SFPQ condensates keep neurons' two-megabase genes transcribing to the end

An Ehime University team reports that SFPQ binds newly made RNA and uses it to build nuclear compartments where elongation, splicing and chromatin remodeling proceed together. Its autism and ALS link rests on overlapping gene lists.

Publishers:neurosciencenews.comphys.org

Reality

Evidence62
Adoption: Insufficient
Hype gap+30
Incentives48
Confidence58