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Xenocortical mouse

Mouse model in which the neocortex and hippocampus are genetically depleted before birth and the resulting cavity is engrafted with human stem-cell-derived cortical organoids.

Known aliases

  • apallial mouse
  • XCX mouse

Relationships

No evidence-backed relationships are recorded.

Current clusters

science5 publishers

Human organoids filled more than 90 percent of the cortex in mice bred without one

A Stanford team emptied the mouse neocortex genetically and grew human cortical organoids into the gap, where the grafts took in 25 of 29 animals, expanded nearly fivefold over three months and wired into the host nervous system.

Perspective Coverage

5 publishers
Builder
Builder 51%
Operator
Operator 33%
Investor
Investor 16%

Reality

Evidence78
Adoption12
Hype gap+18
Incentives55
Confidence70