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Primpol

A human enzyme with both primase and polymerase activity that can restart DNA synthesis past obstacles, an emergency route that leaves gaps and raises the mutation rate.

Known aliases

  • PRIMPOL

Relationships

No evidence-backed relationships are recorded.

Current clusters

science1 publisher

Cohesin reorganizes newly copied DNA where replication stalls

A Nature paper from the University of Zurich and the CNIO reports that cohesin is pulled to sites where DNA replication is disrupted, holds the new copy in a protective arrangement, and keeps the error-prone restart factor Primpol switched off.

Publishers:phys.org

Reality

Evidence60
Adoption
Insufficient
Hype gap+18
Incentives55
Confidence57