other

p38 delta

One of the p38 mitogen-activated protein kinases, a family of signalling enzymes involved in regulating cellular activity. p38 delta has been studied in cancer and other biological processes and is considered hard for drug molecules to bind selectively.

Known aliases

p38 delta kinase
p38δ

Relationships

No evidence-backed relationships are recorded.

Current clusters

science1 publisher

A clash with a flexible loop won an inhibitor 12,000-fold selectivity for p38 delta

Chemists in Tubingen measured the selectivity first and could not explain it. Crystallography at Buffalo found that the molecule bumps a flexible loop on p38 delta, and the loop kinks and wraps around it.

Publishers:phys.org

Reality

Evidence55
Adoption: Insufficient
Hype gap+18
Incentives55
Confidence50