Topic

Ubiquitylation

The enzymatic attachment of the small protein ubiquitin to a substrate, which cells use as a signal for degradation, trafficking and other fates.

Current clusters

science2 publishers

A ubiquitin ligase tags malformed glycogen for disposal in the mouse brain

Researchers at Cambridge and the MRC Laboratory of Molecular Biology report in Nature that the enzyme RNF213 ubiquitylates poorly branched glycogen directly, and that mice without that ligase activity accumulate polyglucosan in three brain regions.

Publishers:nature.comphys.org

Reality

Evidence72
Adoption: Insufficient
Hype gap+18
Incentives55
Confidence68