Topic

Functional genomics

Experimental approaches that test what genomic sequences actually do in cells, rather than inferring function from sequence comparison alone.

Current clusters

science1 publisher

Human joints carry a quarter to a third of the glycosaminoglycan found in other apes

A Nature screen of 561,410 human-derived variants in cartilage cells, cross-checked in human-ape hybrid cells, traces that gap to suppressed glycosaminoglycan biosynthesis, and the authors argue it helps explain human joint disease.

Publishers:nature.com

Reality

Evidence68
Adoption: Insufficient
Hype gap+12
Incentives45
Confidence62

science1 publisher

Human-gorilla hybrid cells show cartilage-cushioning genes dialed down on the human side

A Kyoto and Weizmann team screened 561,000 human-specific regulatory changes in cartilage cells. The survivors were then read inside cells carrying both human and gorilla chromosomes, where glycosaminoglycan genes ran lower on the human copies.

Publishers:phys.org

Reality

Evidence62
Adoption: Insufficient
Hype gap+18
Incentives60
Confidence55