other

RyR1

Ryanodine receptor 1, the calcium-release channel of the skeletal-muscle sarcoplasmic reticulum and the largest known ion channel. Mutations in its gene, RYR1, underlie malignant hyperthermia susceptibility and several congenital myopathies.

Known aliases

Ryanodine receptor 1
RYR1
type-1 ryanodine receptor

Relationships

No evidence-backed relationships are recorded.

Current clusters

science2 publishers

Freezing RyR1 in its own membrane shows muscle calcium channels priming each other open

A Max Delbrück Center team froze rabbit sarcoplasmic reticulum with the channels still in the bilayer and caught six opening states, giving coupled gating a structural account almost 30 years after it was described.

Publishers:genengnews.comphys.org

Reality

Evidence55
Adoption: Insufficient
Hype gap+20
Incentives: Insufficient
Confidence60