Procainamide

Chonnam chemists put dichloromethane to work as an amide coupling reagent

Chonnam National University chemists used dichloromethane as an amide coupling reagent, making more than 20 grams of the drug moclobemide at over 99% purity. The open test is whether using up a chlorinated solvent as a reagent leaves less waste than the coupling reagents it would replace.