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Weill Cornell biophysicists locate where trace PIP2 holds rod-cell CNG channels closed
Weill Cornell biophysicists used cryo-EM to map the pocket where trace amounts of the lipid PIP2 dock onto rod-cell CNG channels and hold them shut. The site is a candidate drug target for inherited retinal degeneration, so far studied only in synthetic membranes.
Publishers:neurosciencenews.com
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