science1 publisher
Adding a D2 agonist to methylphenidate cut impulsive jumping from 78% to 11% in NSF-knockout mice
A University of Fukui team deleted the protein NSF from dopamine D2 receptor neurons in mice. The animals lost cells, dopamine and striatal volume, and the first-line stimulant did nothing for their hyperactivity until a direct receptor agonist went with it.
Publishers:neurosciencenews.com
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