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LGI1

A brain protein involved in signalling between nerve cells; antibodies against it cause a form of autoimmune encephalitis.

Known aliases

  • LGI1 antibodies

Relationships

No evidence-backed relationships are recorded.

Current clusters

science1 publisher

Psychiatrists weigh screening psychosis patients for antibodies that attack the brain

Cambridge psychiatrist Peter Jones saw a patient's hallucinations resist antipsychotics and then fade after plasma exchange for autoimmune encephalitis. The case supports antibody tests in some psychosis, but the evidence for wider screening is still one case and a 12-patient series.

Reality

Evidence40
Adoption
Insufficient
Hype gap+5
Incentives
Insufficient
Confidence50