model

GPN-Star

Genomic language model that conditions on whole-genome alignments and a species tree to score functional constraint and variant effects, with trained versions for the human genome and several model organisms.

Known aliases

genomic pretrained network with species tree and alignment representations

Relationships

No evidence-backed relationships are recorded.

Current clusters

science2 publishers

Berkeley's genome model buys accuracy with alignments instead of parameters

GPN-Star folds whole-genome alignments and a species tree into its architecture, which is how it trains in hours where Evo 2 needed 2,000 processors and months. The cost of building those alignments sits outside that comparison.

Publishers:nature.comphys.org

Reality

Evidence60
Adoption14
Hype gap+28
Incentives72
Confidence58