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A ubiquitin ligase tags malformed glycogen for disposal in the mouse brain
Researchers at Cambridge and the MRC Laboratory of Molecular Biology report in Nature that the enzyme RNF213 ubiquitylates poorly branched glycogen directly, and that mice without that ligase activity accumulate polyglucosan in three brain regions.
Reality
- Evidence72
- Adoption
- Insufficient
- Hype gap+18
- Incentives55
- Confidence68